ICF International
Menu Skip
Perspectives on Environment

Global Climate Change & Stratospheric Ozone Protection Analyses

Air Quality Management

Water Resources

Chemistry & Quality Assurance

Hazardous Materials & Waste Management

Site Assessment & Remediation

Geotechnical & Geoenvironmental Engineering

Critical Infrastructure Protection

Defense Installations Management & Environmental Support

Environmental Impact Assessment

Health & Environmental Risk Assessment

Environmental, Health, & Safety Management

Institution Strengthening

Environmental Due Diligence

Technology Development, Commercialization,
& Transfer


Environment Publications

Environment Site Map

Print This Page

Send to a Friend
""
  

Health & Environmental Risk Assessment

Risk assessment can have the single largest impact on sound environmental decision making. For more than 20 years, ICF International has been a leading pioneer in environmental and human health risk assessment and in the related areas of toxicology and exposure/fate and transport modeling, as well as children's environmental health.

We are noted for developing the Multistage Model for cancer risk assessment and the Benchmark Dose Model for non-cancer risk assessment, as well as developing novel techniques for physiologically-based pharmacokinetic (PBPK) modeling. Most recently, we have conducted several assignments focusing on persistent organic pollutants (POPs) and have conducted studies on toxicity and exposure of suspected endocrine disrupters. Services include the following:

  • Identifying, evaluating, and managing persistent, bioaccumulative, and toxic (PBT) substances
  • Conducting chemical toxicity reviews
  • Modeling environmental pathways and assessing exposures for a wide variety of pollutants
  • Developing methods, models, and guidance
  • Assessing pesticide risk and providing registration support
  • Conducting risk-based ranking, planning, and evaluation
  • Providing regulatory impact assessment and support
  • Assessing site-specific human health and ecological risks, in support of developing cleanup standards and selecting remedies
  • Assessing risks at currently operating and planned industrial facilities
  • Conducting statistical evaluations of site and background data
  • Evaluating consumer product risks
Right Nav Menuj Selected Projects Selected Clients Models
Awards
NASA Civil Service/Contractor Team Award (2004)
Environment Publications
Perspectives—Special Risk Assessment Issue
Downloads
Air Toxics Risk Assessment
Children's Environmental Health
Ecological Services
Environmental Risk Assessment
Health Science Services
International Environmental Services
Persistent, Bioaccumulative, and Toxic (PBT) Substances
REACH Services
Research Links Childhood Lead Exposure to Changes in Violent Crime Rates Throughout the 20th Century
Risk Assessment Services for Litigation Support and Liability Valuation
Toxicology
Get free Acrobat Reader


Our risk assessment group is committed to problem solving in the most accurate and realistic manner possible using state-of-the-art principles and current information from scientific literature. We have successfully completed hundreds of projects for a diverse client base encompassing a wide variety of industrial corporations and industry groups; local, state, and federal governments, both foreign and domestic; and research institutions.

SELECTED PROJECTS
Back to Top

SELECTED CLIENTS
  • American Petroleum Institute
  • Chemical Manufacturers Association
  • U.S. Army Environmental Policy Institute
  • U.S. Department of Defense
  • U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry
  • U.S. Department of Transportation
  • U.S. Environmental Protection Agency (EPA)
  • U.S. Food and Drug Administration (FDA)
  • U.S. Occupational Safety and Health Administration (OSHA)
Back to Top

MODELS
Back to Top

DETAILS OF SELECTED PROJECTS

Superfund Site Wetland Ecological Risk Assessment for the U.S. EPA Region I

ICF International used ecological and human health risk assessments to guide the remedial design for a red maple swamp contaminated by PCBs, pesticides, and metals from an adjacent Superfund site in New Hampshire. By using food chain models, we reduced the costs of risk-based wetland sediment remediation. Key elements included:

  • Conducting laboratory toxicity and contaminant uptake studies to calibrate food chain models
  • Measuring contaminant levels in fish to model risks to humans and wildlife
  • Demonstrating that the groundwater and surface water pollution attenuation functions of the wetland were not impaired and that an adjacent lake was protected by the wetland
  • Comparing site versus reference wetland/pond risks to assess need for remedial action
  • Using deterministic food chain models to evaluate localized "hot spot" risks to specified wildlife species in order to develop cleanup goals and to develop risk reduction curves for comparing three remedial design scenarios

Based on incremental site risks relative to background, we showed that focused wetland remediation was needed, but that no lake remediation was justified. Our risk reduction curves indicated that 70 percent of the risk existing in the 20 acres of contaminated wetland could be eliminated through focused remediation of only 4.7 acres of "hot spots" where total PCB concentrations exceeded 10 mg/kg. By raising the total PCB cleanup goal from 1 to 10 mg/kg and focusing remedial action on the most accessible hot spots, remedial costs were reduced by 75 percent and the collateral damages to the wetland were minimized. The remedial action restored the wetland to its original, baseline condition.

Risk Assessment Design and Support at Fort Campbell, Kentucky, for the U.S. Army

At Fort Campbell, Kentucky, ICF International planned, implemented, and successfully closed a large number of Solid Waste Management Units (SWMUs). Our risk assessors were involved from the beginning of the planning phase, in order to focus and limit the sampling necessary at each SWMU. We were also involved in development of base-wide background values and in the development of a base-wide Fort Campbell Risk Assessment Strategy. Quantitative human health risk assessments for 23 SWMUs were conducted. The complex investigation of hazardous substances at 23 separate SWMUs—and the consideration of 8 potentially exposed populations with 7 potential exposure routes, —necessitated an automated approach.

ICF International developed a human health risk assessment computer program, which could import data from the Army's database. This allowed for a more efficient process, permitting us to more easily quality check the data and the resulting risk analyses. Using our online database capabilities for sample tracking and chemical analysis results, we were able to provide the client with preliminary results indicating the nature and extent of contamination at each SWMU. This information was used to initiate corrective actions, such as soil removal—immediately, if necessary. The risk assessment computer program allows ICF International to provide timely and cost-effective work products to help our clients make site cleanup decisions.

Superfund Site Human Health and Ecological Risk Assessments and Community Relations for the U.S. Army

Concerns associated with potential contamination in a recreational lake, in groundwater, and in dust originating from the site in off-site yards and homes were addressed by ICF International's risk assessors as part of a complete remediation investigation and feasibility study (RI/FS) for the site. Our work included groundwater and air modeling. We also determined site background conditions and the potential health effects of the groundwater treatment system. We participated in all Restoration Advisory Board (RAB) meetings, presenting the risk assessment approach and discussing issues of concern to the community. We also assisted with the preparation of public newsletters, press releases, and annual environmental exhibits at the facility. ICF International met with regulators throughout the planning and completion of the risk assessments and the development of remedial action goals. We incorporated the concerns of the regulators, when possible, or—by participating in negotiations and showing strong scientific support—satisfied the regulators that our approach would work and still would protect human health and the environment. Our interaction on a regular basis with the federal and state regulators in charge of the site investigation allowed the numerous phases of the Remedial Investigation, Feasibility Study, and Treatability Study to proceed on schedule. Finally, we conducted a field study on fish and wildlife in the lake in order to quantify risks to ecological receptors and to people who ingested the lake fish.

Alternative Concentration Limit Demonstration for the U.S. EPA Region I

At the Winthrop Landfill Superfund Site in Maine, ICF International was involved in one of the only successful Alternative Concentration Limit (ACL) Demonstrations in the country. Over a period of five years at this very complex site, we guided the EPA through the ACL Demonstration process, resulting in the setting of alternative concentration limits at points of compliance for a large number of landfill contaminants in groundwater. The work involved human health and ecological risk assessments, development of health and ecological risk-based protective concentration limits at points of exposure (sediments, surface water, seeps), and fate and transport modeling of contaminants in the subsurface between the points of exposure and points of compliance. In addition, ICF International supported the community relations program by assisting the EPA with newsletters, meetings, and public hearings. The ACLs developed were used by the regulatory agencies to set site-specific groundwater cleanup standards.

 

Framework for Product Risk Management for a Major U.S. Trade Association

ICF International provided technical expertise in developing a life cycle risk management framework for industrial products. The system includes tools to evaluate hazard, exposure, and public concern. For hazard, ICF International modified a ranking method to assign chemical-specific scores based on health and environmental effects. For exposure, we developed a multi-tiered assessment framework to provide relative ranking for various exposure scenarios (e.g., disposal after consumer use). For public concern, we prepared a worksheet to assist in identifying high-interest products.

Chemical Scoring and Ranking Systems Review for a Major U.S. Trade Association

ICF International reviewed six scoring systems developed for the purpose of screening and ranking chemicals based on several criteria related to toxicity and exposure potential. For each system, ICF International summarized the system design and implementation, identified strengths and weaknesses, and determined whether the system objectives were met in actual use. Using a sample set of chemicals, a comparative analysis was performed on the outputs of the six systems. ICF International later reviewed modifications to the systems and suggested specific improvements.

Selected Chemicals' Toxicity Testing Review for a Major U.S. Trade Association

ICF International conducted this project in response to complaints from government agencies and the public that the chemical industry conducts inadequate testing of its products. ICF International randomly identified 20 chemicals from a list of 500 candidates and then performed literature searches using several on-line databases to determine the universe of studies conducted on these chemicals. For some chemicals, we discovered more than 800 citations. We built a file for each chemical and prepared a report.

Preparation of Hazardous Substances' Toxicological Profiles for the U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry

As prime contractor, ICF International has prepared 150 toxicological profiles or updates on a subset of hazardous substances found at sites on the National Priorities List for Superfund sites. Based on a literature review and a critical evaluation of toxicological data, ICF International identified minimal risk levels (MRLs), which are exposure levels that are anticipated to be without adverse effects in humans. Profiles or updates are then written to be responsive to the needs of health professionals, scientists, and the general public.

Risk Assessment Guidance for Superfund for the U.S. EPA Office of Emergency and Remedial Response

ICF International provided a full range of analytical research, and technical writing assistance to support development of Risk Assessment Guidance for Superfund: Volume I—Human Health Evaluation Manual and its predecessor, The Superfund Public Health Evaluation Manual (SPHEM). As part of this project, ICF International evaluated several models and parameters that are often used to estimate exposure and risk at hazardous waste sites under different land-use scenarios and for different media. Next, for the selected models, we substituted the relevant parameter values and developed "user-friendly" default equations for calculating preliminary remediation goals. We then developed a spreadsheet program to calculate the necessary clean-up concentrations.

Development of Chemical Inhalation Reference Concentrations (RfCs) for the U.S. EPA National Center for Environmental Assessment

Since 1989, ICF International has provided scientific and technical support in the development of inhalation reference concentration values (RfCs) for more than 120 substances. These values are estimates of daily human exposures over a human lifetime that are unlikely to pose significant risk of adverse health effects. We critically evaluate information on the air pollutant under study, select the critical study and critical effect upon which the RfC will be based, and derive an RfC according to the current interim methodology. We also prepare expert reviews of Benchmark Dose/Benchmark Concentration analyses prepared by EPA.

Nationwide Hazardous Air Pollutant Exposure Assessment for the U.S. EPA Office of Policy, Planning, and Evaluation

To allow EPA to identify the sources of and assess human exposures to air toxics, ICF International has performed a broad study of cumulative exposures to the 189 hazardous air pollutants (HAPs) designated under the Clean Air Act. The objectives of the study, referred to as the Cumulative Exposure Project (CEP), include development of a modeling approach to account for all identified indoor and outdoor source categories. This approach needed to estimate geographic variability of exposures at the census tract level. In addition, a nationwide HAP emissions inventory was developed along with demographic databases.

New York City Radioactive Materials Transportation Risk Assessment for the U.S. Department of Transportation

ICF International performed a risk analysis of three alternative routes for shipments of radioactive materials through New York City. The City had attempted to ban such shipments and consequently became involved in a series of legal proceedings with DOT. Using DOT guidelines for the selection of preferred highway routes for radioactive shipments, ICF International carried out a comparative routing risk assessment using population census data in a GIS format.

Back to Top

DETAILS OF MODELS
Benchmark Dose Method

ICF International is a nationally recognized leader in developing and applying benchmark dose (BMD) models. A BMD is defined as the dose (or concentration) of chemical predicted to result in a specified amount of increased response (called the benchmark response) compared to unexposed controls. The BMD is calculated using a dose-response model applied to either experimental toxicological or epidemiological data. A statistical lower bound on the BMD (referred to as the BMDL) has been proposed as a substitute for the traditional NOAEL or LOAEL in the setting of acceptable exposure limits for non-cancer effects.
PBPK-SIM

Physiologically-based pharmacokinetic (PBPK) modeling is a method used to incorporate the metabolic capability of individuals into chemical risk assessment, thereby providing improved accountability for intrapopulation variability. Using Monte Carlo simulation techniques, PBPK-SIM accounts for the impact of human heterogeneity on the risk to a specific individual as compared to the average population risk. PBPK-SIM automates the running of several PBPK model simulations where the dose inputs or parameter values can change from simulation to simulation. It links the PBPK modeling results to dose-response modeling. Finally, PBPK-SIM calculates statistics to describe the variability (uncertainty) associated with any user-selected output variables, whether those are dose surrogates (variables from the PBPK model) or risk estimates.
Back to Top


 

Contact us via e-mail at info@icfi.com Contact us by phone at 1.703.934.3603