ICF International has developed a Microsoft Excel-based tool known as the BMDS Wizard that allows a user to run multiple consecutive modeling sessions in the U.S. Environmental Protection Agency's (EPA) Benchmark Dose Modeling Software (BMDS). The BMDS Wizard stores all inputs, outputs, and decisions made in the modeling process.
All benchmark-dose modeling is conducted using EPA's BMDS software; the BMDS Wizard acts as a "shell" surrounding BMDS. The BMDS Wizard simplifies the BMD modeling process by streamlining data entry and option file development, implementing logic to help compare and evaluate models, and automating the documentation in a report format. It is capable of analyzing continuous, dichotomous, and dichotomous-cancer datasets. The Wizard stores all inputs and output from BMDS, including output files and image files, in the Microsoft Excel workbook.
The BMDS Wizard recommends best-fitting models based on customizable, user-defined decision logic. A user may choose to agree or disagree with the model recommendations made by the BMDS Wizard. Once a user selects a best-fitting model, the BMDS Wizard can generate a Microsoft Word summary report of the results. Model recommendation criteria are based primarily on EPA's 2012 Benchmark Dose Technical Guidance1. The BMDS Wizard is designed to integrate with DRAGON software that stores experimental study details in addition to the dose-response data used in a comprehensive risk assessment.
Current Release: Version 1.10 (updated October 2014)
Download the latest version of the BMDS Wizard at no cost. The download consists of a zip file containing the BMDS Wizard, other required files, installation instructions, and documentation.
- Windows XP, Vista, or 7
- Microsoft Excel 2007+
- Microsoft Word 2007+
- U.S. EPA BMDS Software (version 2.5)
BMDS Wizard is not endorsed or approved by the EPA.
1 U.S. Environmental Protection Agency. 2012. Benchmark Dose Technical Review Draft. http://www.epa.gov/raf/publications/pdfs/benchmark_dose_guidance.pdf
The BMDS Wizard is designed to integrate with the DRAGON software currently being developed by ICF. Learn more about DRAGON, which is used to store dose-response information commonly used in a risk assessment.
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Senior Technical SpecialistICF International
Cara Henning has six years of professional experience in exposure and risk assessment, air quality modeling, statistical modeling, and quantitative analysis. She has broad experience using and developing a wide range of exposure and risk modeling tools, including biokinetic and physiologically-based pharmacokinetic models (multiple models for exposure to lead, dioxin, cadmium, and perchlorate), dose-response models (BMDS), indoor air-quality models (MIASMA, designed by ICF; renovation rule indoor lead exposure model, designed by ICF), point source and area source emission models (SLAB and ALOHA), population exposure models (HAPEM and APEX), construction emission models (URBEMIS), and traffic emissions models (CALINE4). She has particular experience building model processing tools to facilitate running exposure and risk models in batch mode for applications such as probabilistic analysis or sensitivity analysis. Currently, she is assisting in the development of the cadmium IRIS documents and the dioxin reassessment. Dr. Henning's areas of expertise include physical modeling, statistical and probabilistic modeling, Fortran and VBA coding, database management, and data analysis.
Dr. Henning has a Ph.D. in Atmospheric and Oceanic Science from Princeton University and a B.S. in Physics with Honors and Highest Distinction from the University of North Carolina.
Senior AssociateICF International
A.J. Overton provides support to clients in the areas of human health and environmental risk assessment, air quality analysis, database development, and statistical analysis.
Mr. Overton has experience in modeling chemical fate and transport in the environment, assessing environmental exposure, and developing software tools to streamline modeling applications and data analysis. He is also a lead for developing Access®-based database solutions, and he supports ICF's statistical team using SAS® 9.3.
Mr. Overton has a B.S. in Biology with a concentration in Environmental Toxicology.
Technical SpecialistICF International
Since joining ICF, Pam Ross has used her toxicology expertise to support human health risk assessments for the U.S. Environmental Protection Agency (EPA). Ms. Ross has assisted in the preparation of several Integrated Risk Information System (IRIS) Toxicological Reviews. She has performed Benchmark Dose Modeling using EPA’s Benchmark Dose Software (BMDS) for relevant toxicity endpoints. She also has served as primary author for the development of provisional peer-reviewed toxicity value documents (PPRTVs) for the Superfund Technical Support Center.
Ms. Ross holds an M.S. in Public Health with a concentration in Environmental Health Sciences.
Senior ManagerICF International
Audrey Turley brings her experience in scientific workshop planning, training development, exposure modeling, and human health risk assessment. Ms. Turley has planned and executed several workshops, bringing together scientists to discuss a variety of topics, including goals for a nanomaterials research strategy, the interactions between climate and nitrogen, the National Ambient Air Quality Standards (NAAQS) for lead, and the U.S. Environmental Protection Agency (EPA) NexGen risk assessment framework. She currently leads the development of a series of training courses that describe the EPA’s approach to conducting human health risk assessment.
Ms. Turley has an M.S. degree in Mechanical Engineering from North Carolina State University and a B.A. degree in Mathematics from Texas A&M University.
Senior ManagerICF International
Joshua Cleland has 20 years of experience providing technical support for U.S. federal environmental quality and food safety regulatory programs. His areas of expertise include chemical exposure and risk assessment, environmental modeling, and federal laws and regulations pertaining to solid and hazardous waste management, air and water pollution control, food safety, organic foods, and biotechnology.
Mr. Cleland has used Microsoft Access and Visual Basic for Applications to create more than 30 user-friendly information management and decision support tools and models for the U.S. Environmental Protection Agency (EPA), Food and Drug Administration (FDA), Department of Agriculture (USDA), Federal Aviation Administration (FAA), and other clients. For example, he built a risk-ranking model for FDA to evaluate chemicals in imported aquaculture products, a tool for USDA to aggregate salmonella monitoring data from poultry production facilities, and a tool for FAA to estimate atmospheric emissions from commercial space flight programs. For EPA, he developed the Multimedia Ingestion Risk Calculator (MIRC), a model to estimate human health risk from chemical exposures through diet and other noninhalation exposure pathways.
Mr. Cleland holds a master’s degree in Natural Resource Economics and Policy from Duke University and a bachelor’s degree in Biology from the University of Michigan.