Classification and Labeling

Categorized Under: Environment



ICF International has made classification and labeling recommendations for hundreds of industrial chemicals. For multiple European-based chemical consortia, ICF has reviewed data to make recommendations for classification and labeling in accordance with Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labeling, and packaging of substances and mixtures (CLP). ICF has also classified substances according to the Globally Harmonized System (GHS) of Classification and Labeling for European chemical consortia and international chemical companies.

To determine if a substance is classified and labeled under CLP and/or GHS for a specific human health or environmental endpoint, ICF reviews previous classifications under other regulations combined with references from comprehensive literature searches and proprietary studies supplied by the client to form the basis for each toxicological or environmental assessment. Toxicokinetic, acute, subchronic, chronic, irritation, sensitization, carcinogenicity, mutagenicity, reproductive toxicity, developmental toxicity, physicochemical, environmental fate, and ecotoxicity data are then objectively analyzed to identify critical effects, data deficiencies, and no-observed-adverse-effect-level (NOAELs) or lowest-observed-adverse-effect-level (LOAELs).

In the absence of test data, ICF has extrapolated (read-across) to other structurally similar data-rich substances or classes of substances using structure-activity relationship strategies. When reliable data on a specific substance are lacking or the available data reports conflicting results, ICF scientists have used expert judgment and weight-of-evidence arguments to make classification and labeling recommendations.ICF's experience using read-across strategies and weight-of-evidence arguments has provided our clients with classification and labeling recommendations in accordance with new and recently updated regulations. These recommendations have been used to populate safety data sheets in the United States and Europe and have also been incorporated into REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) chemical registration dossiers.

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Insight Details

Client: European chemical company consortia, International chemical companies
Location: Global

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