The United States has dispersed more than $604 million to combat human trafficking around the world since fiscal year (FY) 2001 (Department of State 2009). While these efforts have undoubtedly influenced and shaped the global anti-trafficking movement over the last decade, a July 2006 Government Accountability Office (GAO) report to Congress found that the “U.S. government has not developed a coordinated strategy to combat human trafficking abroad” and has “not focused on developing and implementing a systematic way for agencies to…identify targets of greatest need and leverage overseas activities to achieve greater results” (GAO 2006). These findings emphasize the need for the U.S. to develop a coordinated strategy that links evidence-based practice with clear funding priorities to continue leading the global fight against modern-day slavery. This paper seeks to outline several recommendations for the U.S. government to continue to lead the fight against human trafficking by setting clear priorities for shaping effective interventions on the ground.