White Papers

Protecting Public Health in the 21st Century

The Case for Computational Toxicology

Categorized Under: Environment, Health



This ICF International white paper discusses how computational methods have been applied to address a number of important issues central to improving human health hazard and risk assessment. The paper outlines how to develop a defensible path forward using modern tools of toxicology while addressing several challenges to protect public health.

Advances in knowledge—about the modes of action for chemical toxicity, development of new hazard screening and in vitro testing technologies, and the need for ensuring public health when the number of chemicals in commerce is rapidly increasing—drive the need for advanced computing capacity in the areas of toxicology and risk assessment. Ensuring the nation’s health and safety from exposure to chemicals has never been more complicated. Risk managers, regulators, and other decision makers in agencies charged with this mission face increasingly complex challenges that require the best available science and tools. As a result, rapidly evolving computational toxicology methods are being developed to help protect the public from these hazards in a technically rigorous, cost-effective, and timely manner.

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Authored By

  • Bill Mendez

    Senior FellowICF International

    Dr. Bill Mendez has more than 30 years’ experience in scientific consulting and project management. He has expertise in toxicology, environmental chemistry, human health risk assessment, statistical analysis, and environmental policy evaluation. He supports the Environmental Protection Agency (EPA) National Center for Environmental Assessment (NCEA) and its Integrated Risk Information System (IRIS) program. He is participating in a cancer and noncancer risk assessment for inorganic arsenic and in the development of the IRIS Toxicological Review for cadmium.

    He was the Lead Scientist on the Office of Air Quality Planning and Standards’ (OAQPS’) quantitative risk assessment in support of revisions to the National Ambient Air Quality Standard for Lead.

Insight Details

Published: Nov 28, 2011
Authors: ,

Russell Savage

Source: ICF International

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