This ICF International white paper discusses how computational methods have been applied to address a number of important issues central to improving human health hazard and risk assessment. The paper outlines how to develop a defensible path forward using modern tools of toxicology while addressing several challenges to protect public health.
Advances in knowledge—about the modes of action for chemical toxicity, development of new hazard screening and in vitro testing technologies, and the need for ensuring public health when the number of chemicals in commerce is rapidly increasing—drive the need for advanced computing capacity in the areas of toxicology and risk assessment. Ensuring the nation’s health and safety from exposure to chemicals has never been more complicated. Risk managers, regulators, and other decision makers in agencies charged with this mission face increasingly complex challenges that require the best available science and tools. As a result, rapidly evolving computational toxicology methods are being developed to help protect the public from these hazards in a technically rigorous, cost-effective, and timely manner.
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